Reperfusion Injury, Microvascular Dysfunction, and Cardioprotection
نویسندگان
چکیده
منابع مشابه
MINI-SYMPOSIUM Management of microvascular dysfunction and reperfusion injury
T he aim of reperfusion therapy for acute myocardial infarction (AMI) is to rapidly restore coronary blood flow and myocardial perfusion with the objective of salvaging myocardium. The treatment of AMI for many years has focused on achieving patency of the conduit epicardial artery at the site of plaque rupture and occlusive thrombus. Major advances in interventional techniques and adjunctive p...
متن کاملSpotlight on cardioprotection against ischemia-reperfusion injury.
Worldwide, coronary heart disease (CHD) causes approximately one-third of all deaths in men and one-quarter of all deaths in women and represents a significant threat to public health. The global burden of CHD in terms of disability-adjusted life years (DALY) or " healthy years of life lost " is projected to increase from around 47 million DALY globally in 1990 to 82 million in 2020 [1]. Myocar...
متن کاملCardiac Na/K-ATPase in ischemia-reperfusion injury and cardioprotection
............................................................................................................................. iii Acknowledgements ..............................................................................................................v Table of
متن کاملPast and present course of cardioprotection against ischemia-reperfusion injury.
Despite tremendous advances in cardiovascular research and clinical therapy, ischemic heart disease remains the leading cause of serious morbidity and mortality in western society and is growing in developing countries. For the past 5 decades, many scientists have studied the pathophysiology of myocardial ischemia-reperfusion (I/R) injury leading to infarction. With the exception of reperfusion...
متن کاملPreconditioning and postconditioning: innate cardioprotection from ischemia-reperfusion injury.
Reperfusion is the definitive treatment to salvage ischemic myocardium from infarction. A primary determinant of infarct size is the duration of ischemia. In myocardium that has not been irreversibly injured by ischemia, reperfusion induces additional injury in the area at risk. The heart has potent innate cardioprotective mechanisms against ischemia-reperfusion that reduce infarct size and oth...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2009
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.108.814640